A study of renal manifestations in hypothyroid patients  found during  pre anesthetic check up.

Mahmood Mirza

Volume : VI, Issue : V, May - 2016

A study of renal manifestations in hypothyroid patients found during pre anesthetic check up.

Mahmood Mirza

Abstract :

Introduction: Thyroid hormone influences renal development , kidney structure , renal heamodynamics ,GFR , the functions of many transport system along nephron , sodium and water homeostasis . Disorder of thyroid function can result from any abnormality that leads to insufficient synthesis of thyroid hormone .The most common primary hypothyroidism is linked to immune mediated glomerular injury and alteration in the production of thyroid hormone .The presence of hypometabolic state thus necessitates careful perioperative renal ,cardiovascular monitoring and judicious use of anaesthetic drugs. Aim :The present study was aimed to analyse renal parameters – blood urea , serum and urinary creatinine , serum and urinary electrolytes in patients with history of hypothyroidism posted for elective surgery during the year 2015 at deccan college of medical sciences . Material and method : The following biochemical parameters derived were estimated glomerular filtration rate (eGFR) and fractional excretion of sodium (FeNa). 50 people were taken as controls that had no medical illness and 50 cases of incidental subclinical hypothyroidism were taken as case study group . Mean and Standard deviation was assessed and p value ≤0.05 was considered significant. Result: The mean and SD of blood urea (mg/dl) in controls is 28.2±4.75 as compared to 27.29±8.1 in cases . The P value is not significant . The mean and SD of serum creatinine (mg/dl) in controls was 0.7±0.15 as compared to 1.10±0.24 in cases .The P value was <0.01 which is significant . The mean and SD of electrolytes sodium , potassium and chlorides in controls were 140.4±2.15 , 4.06±0.25 and 98.3±2.25 as compared to case study group of 147.93±6.98 ,4.15±0.42 and 107.81± 10.35 The P value of serum sodium and chloride is <0.01 which is significant . The p value of potassium is not significant .