A STUDY OF SERUM LDH ACTIVITY IN LEUKEMIC PATIENTS BEFORE AND AFTER CHEMOTHERAPY

Jadab Kishore Phukan; Lipika Buzarbaruah

Volume : VI, Issue : VIII, August - 2016

A STUDY OF SERUM LDH ACTIVITY IN LEUKEMIC PATIENTS BEFORE AND AFTER CHEMOTHERAPY

Jadab Kishore Phukan, Lipika Buzarbaruah

Abstract :

Leukaemias are malignant disorders of the haematopoietic stem cell compartment, characteristically associated with increased numbers of white cells in the bone marrow and/ peripheral blood. Once the diagnosis of leukemia is suspected, a rapid evaluation and initiation of appropriate treatment is necessary because of its overwhelming impact on prognosis in terms of achieving complete remission or providing a better quality of life for a longer period of time. The study was being undertaken to study and correlate the serum LDH activity in leukemic patients before and after 1 month of chemotherapy. And also to evaluate the utility of serum LDH activity as a prognostic index. The present study was carried out among 30 patients admitted in different units of Medicine and Pediatrics department of Assam Medical College & Hospital, Diugarh, during a period of one year. The type of study done was a Case–Control Clinical Cross–over Study. The difference between the means of serum LDH activity of leukemic patients and the corresponding means of controls have been found to be significant at Diagnosis and After 1 month of Chemotherapy. The difference in serum LDH activity between CML and ALL patients before and after 1 month of chemotherapy was significant. Serum LDH activity increases in leukemic patients and there is a significant reduction after chemotherapy. So the study concludes that biochemical alteration of serum LDH activity can play an important role in the prognostic aspect of the disease.