A STUDY OF SERUM TOTAL CALCIUM AND SERUM CALCIUM / PHOSPHORUS RATIO IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH SEVERITY OF THE DISEASE

Raman Prabhakaran; Syed Bahavudeen Hussaini; Domeh; Vijayakumari Vrinda; Ahamed Kalil

Volume : VII, Issue : V, May - 2017

A STUDY OF SERUM TOTAL CALCIUM AND SERUM CALCIUM / PHOSPHORUS RATIO IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH SEVERITY OF THE DISEASE

Raman Prabhakaran, Syed Bahavudeen Hussaini, Domeh, Vijayakumari Vrinda, Ahamed Kalil

Abstract :

CONTEXT Hypertension is an increasingly important medical and public health burden globally. In this study, we attempt to review the evidence that altered calcium metabolism, thereby change in serum calcium levels are implicated in primary hypertension. AIM OF THE STUDY To study the levels of serum Total Calcium and serum Calcium / Phosphorus ratio in patients with primary hypertension. To correlate the serum Total Calcium level and serum Calcium / Phosphorus ratio with blood pressure SETTINGS AND DESIGN Analytical Case Control Study. MATERIALS AND METHODS This study is conducted among 50 ischemic stroke patients who were admitted at Government Rajaji Hospital, Madurai from December 2014 to June 2015. After taking detailed history and physical examination and investigations, MPV was determined for Ischemic stroke patients and Modified Rankin scale (MRS) at the time of admission was calculated. After 8 weeks of onset of stroke, all the patients were again followed up. Functional outcomes were determined by use of Modified Rankin Scale (MRS)2,3. All patients were stratified using MRS2,3 Scale [0–2, 3–4 and 5–6] into three groups. MPV level was correlated with MRS score at the time of admission and again at 8 weeks. Patients with MRS score of 5 and 6 were declared as very poor outcome & MRS of 3 and 4 as poor outcome. Patients with MRS 0, and 1 were considered as good outcome. STATISTICALANALYSIS Standard deviation , regression analysis , mean , median . RESULTS There is no statistically significant difference among the case and control groups with regard to the age or sex composition or smoking or alcoholism. MPV did not vary with diabetes or hypertension. There was a linear relation with MPV and severity of ischemic stroke i.e. as the MPV increases the severity (MRS) 2,3of stroke increases. CONCLUSIONS There is significant elevation of Mean platelet volume in ischemic stroke patients1 compared to matched control group. Mean platelet volume can be used as a significant risk factor for acute ischemic stroke and other vascular events independent of other risk factor.