A study of thyroid abnormalities in first episode and recurrent depressive disorder

Volume : VIII, Issue : V, May - 2018

Dr. Manish Borasi, Dr. Hemika Agrawal, Dr. Nimesh G Desai, Dr. Vijender Singh, Dr. Neelam Chhillar

Introduction: Depression is one of the leading causes of disease worldwide. Depression is not only a common, often

chronic, and recurrent disorder, but it is cardinally associated with signicant impairment in work and daily social and

psychological well–being. Depression is projected to be the second leading cause of disease burden for both men and women across age groups

by the year 2020. A key variable inuencing rates of recovery, relapse, and recurrence is the presence of medical or psychiatric comorbid

illnesses. Among medical co–morbid illness, thyroid abnormalities are very common. Both excess and insufcient thyroid hormones can cause

mood abnormalities including depression that is generally reversible with adequate thyroid treatment.

Materials and method: The study was carried out over a period of 9 months on patients registered in psychiatry clinic at tertiary neuropsychiatry

center suffering from depressive disorder as per the ICD–10(DCR). Then after applying inclusion and exclusion criteria and explaining the

purpose of study, those patients who give consent were included. Severity of depression will be rated using HAM–D. Thyroid prole of those

patients who gave consent were done in laboratory of neurochemistry department. The results thus generated were subjected to appropriate

statistical analysis.

Results and conclusion: Our study reveals that 12% of the subjects had decreased T3 levels, 36% subjects were found to have increased TSH

levels . Subclinical and clinical hypothyroidism were seen in 35% of subjects with depressive disorder.The occurrence of subclinical

hypothyroidism was more common in RDD (25.9%) in comparison to rst episode (19.6%).