A STUDY OF VALIDITY OF HAEMATOLOGICAL PARAMETERS IN THE DIAGNOSIS OF NEONATAL SEPSIS

MANOJ BARMAN; BARNALI DAS

Volume : VI, Issue : III, March - 2016

A STUDY OF VALIDITY OF HAEMATOLOGICAL PARAMETERS IN THE DIAGNOSIS OF NEONATAL SEPSIS

Manoj Barman, Barnali Das

Abstract :

Background:The current study is undertaken to study the validity of haematological parameters in the early diagnosis of neonatal septicemia using Rodwell”s scoring criteria which includes simple laboratory tests such as total leucocyte count (TLC),absolute neutrophil count (ANC),immature neutrophill count (I),immature to to? tal neutrophil ratio (I:TNR),immature to mature neutrophil count ratio,platelet count and degenerative changes in neu? trophils. Materials and methods: Infants were enrolled in the study if there were predisposing perinatal factors or if there was clinical suspicion of sepsis. The HSS assigns a score of one for each of the seven criteria found to be significantly as? sociated with sepsis with one exception. An abnormal total count is assigned a score of 2 instead of 1, if no mature polymorphs are seen on the peripheral smear to compensate for the low I:M ratio. Sensitivity, specificity, positive and negative predictive values were evaluated for each of the seven criteria of HSS. Results:From the present study it was found that out of 50 cases with culture proven sepsis, 42 (84%) infants had score ≥5, and 8 (16%) had scores 3?4.42 out of 50 cases which were culture positive,were also sepsis positive on HSS.HSS has a sensitivity of 84%, specificity of 77.15% . Conclusion:Hematologic scoring system (HSS) should improve the efficiency of the CBC as a screening test for sepsis until a reliable diagnostic test is available.