A study on alteration in serum lipid profile pattern in oral submucous fibrosis

Dr. Mangesh Shenoy P.; Dr. Radhika Shenoy

Volume : V, Issue : XI, November - 2015

A study on alteration in serum lipid profile pattern in oral submucous fibrosis

Dr. Mangesh Shenoy P. , Dr. Radhika Shenoy

Abstract :

 Introduction: Oral submucous fiosis (OSMF) is a chronic disease of the oral cavity. Alteration in lipid profile has been associated with malignancies as lipids are required for maintenance of structural and functional integrity of cell memane. Material and Methods: The study was conducted on 45 clinically and histopathologically diagnosed cases of OSMF and 45 age and sex matched controls. Lipid profile including Total cholesterol, Triglycerides, HDL cholesterol, LDL cholesterol and VLDL cholesterol were estimated. Results: There was significant reduction in serum lipid levels in the patients with OSMF when compared with the controls. The reduction in lipid levels was maximum in stage 3 OSMF when they were compared among the different stages. The present study demonstrated that the level of serum lipids decreased with progression of the disease. Conclusions: From these findings, it appears that the lower serum lipid levels may be considered as a useful indicator in diagnosis of initial changes occurring in oral premalignant condition like OSMF