Volume : VII, Issue : IX, September - 2017

A STUDY ON ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CISSUS QUADRANGULARIS

Dr. K. Geetha, Dr. M. Malathi

Abstract :

 AIM & OBJECTIVE:   To evaluate the anticonvulsant effect of aqueous extract of Cissus quadrangularis in MES induced seizures, in adult male albino rats in comparison with diphenyl hydantoin.  

MATERIALS AND METHODS: 15 adult male albino rats weighing 250–300g, were divided into five groups of three each. Group I which served as control received 0.5 ml of 1% gum acacia; Group II (standard) – received diphenylhydantoin; Groups III, IV and V received the test compound– aqueous extract of Cissus quadrangularis at a graded dose of 100,150 and 200 mg/kg body weight respectively. After 2 hours of oral feeding, convulsions were induced 10 minutes apart in each animal and the phases of convulsion along with its duration were observed.

RESULTS :  The duration of tonic extension and post ictal depression were significantly shortened in experimental groups (Groups II and V) compared to control (Group I). The reduced duration of these components are due to the anticonvulsant effect of the drug and the extract which indicates that the aqueous extract of Cissus quadrangularis possesses significant anticonvulsant effect. 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.K.GEETHA, Dr.M.MALATHI, A STUDY ON ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CISSUS QUADRANGULARIS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-9 | September-2017

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