A Study on Assessment of Glycemic Control of Oral Hypoglycemic Drugs and Insulin in Type 2 Diabetes Mellitus Patients

Krishnan Karthickeyan; Perumal Panneerselvam; Thomas Abhilash; Ramalingam Kameswaran; Kandasamy Krishnaveni; Sivannan Srinivasan

Volume : VIII, Issue : IV, April - 2018

A Study on Assessment of Glycemic Control of Oral Hypoglycemic Drugs and Insulin in Type 2 Diabetes Mellitus Patients

Krishnan Karthickeyan, Perumal Panneerselvam, Thomas Abhilash, Ramalingam Kameswaran, Kandasamy Krishnaveni, Sivannan Srinivasan

Abstract :

Introduction

Insulin will be preferred as add–on therapy while the oral hypoglycemic (OHG) drugs are most often failed to control hyperglycemia in patients with chronic diabetes mellitus. The present study assesses the glycemic control in diabetes patient used Insulin and OHG drugs.

Methods

This prospective observational study was conducted in Chennai with a total of 129 diabetes mellitus patients. The patients with fasting blood sugar (FBS) >110 mg/dl and /or random blood sugar (RBS) >150 mg/dl and/or urine sugar level >50 mg/dl were enrolled. The patient’s biochemical and vital physiological parameters were checked at every 30±3^th day over 6 months excluded the first day of patient enrol. The average values were compared by use of paired sample‘t’ test and statistical significance was set at p<0.05.

Results

Among all, except body temperature all parameters were exhibited significant in both groups (p<0.05). The FBS and RBS were not showed significant changes though a combination therapy with Metforminand Glipizide, Glibenclamide and Glimepiride in OHG drugs treated patients than Insulin treated patients. The changes in characteristics in both study groups over 6 months were shown oscillating. The treatment outcome measures were showed similar non significant improvement in patients treated with OHG drugs.

Conclusion

This study results showed the treatment outcome measures were not significantly improved in OHG drugs patients than Insulin treated patients. It reveals that addition of Insulin could have been better in poorly controlled hyperglycemia in combination with Metformin to achieve higher reduction in long term hyperglycemia control so that the hyperglycemia symptoms would have been improved.