A Study on Clinico–Biochemical Profile of Neonatal Seizure in a Tertiary Care Centre in Eastern Bihar.

Dr. Pawan Kumar Yadav; Dr. Anil Kumar; Dr. Brajesh Kumar

Volume : VIII, Issue : VIII, August - 2018

A Study on Clinico–Biochemical Profile of Neonatal Seizure in a Tertiary Care Centre in Eastern Bihar.

Dr. Pawan Kumar Yadav, Dr. Anil Kumar, Dr. Brajesh Kumar

Abstract :

Background: A neonatal seizure is a form of neurological dysfunction that affects a newborn. Biochemical disturbances occur frequently in neonatal seizures either as an underlying cause or as associated abnormalities. In their presence, it is difficult to control seizures and there is a risk of further ain damage. Early recognition and treatment of biochemical disturbances are essential for optimal management and satisfactory long–term outcome. Aims and Objectives:The aims were to study the biochemical abnormalities in neonatal seizures and to describe the clinical presentation, time of onset and its relation to etiology of neonatal seizures. Methods: The present study included 230 neonates presenting with seizures admitted to neonatal unit, in JawaharLal Nehru Medical College and Hospital(JLNMCH), Bhagalpur, Bihar, in the Department of Pediatrics, during the period from October 2016 to December 2017. Results: In the present study, 80% cases had onset of seizures within first 3 days. The highest number is seen on first day of life 57.4%. Subtle seizures were the most common type of seizures 42.6%. Birth asphyxia was the most common cause of neonatal seizures 56%, followed by neonatal meningitis21% and metabolic disorders 11%. The most common biochemical abnormality detected in neonatal seizures in our study was hyponatremia 65%. Conclusions: The most common etiology of neonatal seizures is HIE and onset is during first 3 days of life. Hyponatremia is the most common biochemical abnormality associated with non–metabolic seizures, mainly HIE. Hypoglycemia is a more common metabolic disorder, more so in low birth weight.