A Study on Complement Components (C3, C4) as Inflammatory Markers in Asthma in a Tertiary Care Centre in Eastern Bihar.

Dr Brajesh Kumar; Dr Sushil Bhushan; Dr Anil Kumar

Volume : VII, Issue : VI, June - 2017

A Study on Complement Components (C3, C4) as Inflammatory Markers in Asthma in a Tertiary Care Centre in Eastern Bihar.

Dr Brajesh Kumar, Dr Sushil Bhushan, Dr Anil Kumar

Abstract :

Objective: To analyze the serum levels of complement factors C3 and C4 in in a tertiary care centre in asthmatic children in Eastern Bihar. Methods: In a Case Control Study, Serum levels of the C3 and C4 complement components were assayed in 120 children aged from 2 to 12 years with the diagnosis of onchial asthma (not in acute attack) and 120 age–and sex–matched healthy controls. All children were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count and serum complements (C3, C4). Results: In the present study it was found that Serum C3 was significantly higher in asthmatics when compared to controls (140.60 ± 38.80 mg/dl vs 107.70 ± 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30±48.80 mg/dl vs 44.60 ± 39.70 mg/dl respectively, p = 0.69). A significant positive correlation was found between severity of asthma and serum C3 (p=0.02) but not with serum C4. Conclusions: We observed that Serum levels of C3 are elevated in children with stable asthma in majority of children but not with C4 and there was also a positive correlation between serum C3 and severity of asthma.