A STUDY ON “CORRELATION BETWEEN MICROALBUMINURIA AND ACUTE ISCHEMIC STROKE IN NON�DIABETIC PATIENTS AND ITS PROGNOSTIC SIGNIFICANCE IN STROKE PATIENTS”

Dr. K.S. Amaravathi; Dr. G.Balaraju; Dr. P. Sakuntala; Dr. S. Sreevani

Volume : VI, Issue : IX, September - 2016

A STUDY ON “CORRELATION BETWEEN MICROALBUMINURIA AND ACUTE ISCHEMIC STROKE IN NON�DIABETIC PATIENTS AND ITS PROGNOSTIC SIGNIFICANCE IN STROKE PATIENTS”

Dr. K. S. Amaravathi, Dr. G. Balaraju, Dr. P. Sakuntala, Dr. S. Sreevani

Abstract :

Background: Microalbuminuria(MA) is thought to be a marker of abnormal vascular permeability and its presence is considered as kidney’s notice for markedly enhanced cereovascular risk. It is considered as an indicator of increased mortality in diabetes mellitus, hypertension and acute myocardial infarction. Objectives: The aim of the study was to evaluate the incidence of microalbuminuria in patients with acute ischemic stroke and prognostic significance of microalbuminuria in these patients. Methodology: The present study included 100 patients admitted into Osmania General Hospital diagnosed with ischemic stroke confirmed by CT scan ain, within 24 hours after the onset of symptoms. The control group consisted of 100 age and gender matched subjects examined within 6 to 12 months after ischemic stroke. Patients with diabetes, abnormal urine analysis, renal insufficiency, systemic infection, smoking, alcoholism, previous vascular events were excluded from the study. The severity of neurologic deficit was measured by the Scandinavian Stroke Scale (SSS). The albumin excretion rate was measured using spot urine collection by Micral Test. The patients were re–examined 6 weeks later for the assessment of activities of daily living using Barthel’s Index. Results: Microalbuminuria was found in 47 of 100(47%) patients with acute ischemic stroke and 10 0f 100(10%) of controls. Patients with microalbuminuria scored lower on Barthel’s Index 6 weeks later. Conclusion: The present study found that patients with acute ischemic stroke were 4.7 times more likely to have microalbuminuria when compared to the controls. Measuring albumin excretion rate seems to be a reliable indicator of outcome 6 weeks after the stroke.