A study on  Drug induced hepatotoxicity during  Antiretroviral therapy for HIV/AIDS

Dr.E.Kandasamy alias Kumar; Dr.K.Caroline Selvi

Volume : VII, Issue : II, February - 2017

A study on Drug induced hepatotoxicity during Antiretroviral therapy for HIV/AIDS

Dr. E. Kandasamy Alias Kumar, Dr. K. Caroline Selvi

Abstract :

Aim:To find out the clinical profile and risk factors for the hepatotoxicity in patients receiving ART therapy for AIDS.Materials and Methods:A total of 1250 patients were screened and patients who developed liver injury during ART therapy were selected. About 50 adult patients of both the sexes were included in the study. Records of these patients were analysed. Further testing was done as needed. Various parameters were noted. Statistical analysis was done by Oneway ANOVA F test, in which correlation between various parameters and hepatotoxicity were analysed. Results were tabulated and compared with various published series worldwide.Conclusion: As per this study the major risk factors for hepatotoxicity were Hepatitis Binfection,Hepatitis C Infection, Low CD4 counts, alcohol abuse in HBV ,HCV positive patients.The risk of liver injury was independent of age, sex,BMI, various drug combinations,Duration of ART. These results were comparable with published series from various countries although subtle differences exist.