Volume : VII, Issue : I, January - 2017

A STUDY ON “ENDOTHELIAL DYSFUNCTION IN PRE DIABETES AS EVIDENCED BY FLOW MEDIATED VASODILATATION”

Dr. V. Shiva Prasad, Dr. D. Sridhar

Abstract :

             

BACKGROUND

 

             

              Endothelial dysfunction is an early event in atherosclerosis and is known to appear long before the formation of structural atherosclerotic changes. Assessment of endothelial function, thus, can provide valuable insight into pre–intrusive phase of atherosclerosis and can be used as  an early marker of future Atherosclerotic disease .Flow mediated dilation (FMD) is known to depend on ability of the endothelium to release NO in response to shear stress and can be used reliably as an estimate of endothelial function in various disease states. Pre diabetic state  characterized by impaired glucose tolerance leads to endothelial dysfunction through  insulin resistance state ,implicating the necessicity for identification of endothelial dysfunction at an early stage and treat it.

AIM OF STUDY: To study the occurrence of endothelial dysfunction in pre diabetics and to correlate various risk factor in pre diabetics with endothelial dysfunction.

 

METHODOLOGY:

 

 Endothelial function was assessed non–invasively by high resolution Duplex Doppler Ultrasound of Brachial Artery in fifty  pre diabetics  cases who were included based on impaired fasting glucose (IFG). FMD was calculated as percentage  increase in achial artery diameter in response to increase in achial artery flow.

 

 

 

 

RESULTS

 

In this study endothelial dysfunction is observed in 3(6%) out of 50 pre diabetics ,out of them 2

 (4.65%) being  male and 1(14.28% )being female. Among these pre diabetic individuals

endothelial dysfunction occurred in individuals who have greater BMI (p<0.017%); HbA1c >6% (p<0.001)  and males with greater waist /hip ratio (p<0.001).

CONCLUSION

Endothelial dysfunction as assessed by FMD is also documented in pre diabetic state . Its

 

occurrence is in correlation with risk factors such as obesity ,higher HbA1c at time of  diagnosis.

 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. V. Shiva Prasad, Dr. D. Sridhar, A STUDY ON ENDOTHELIAL DYSFUNCTION IN PRE DIABETES AS EVIDENCED BY FLOW MEDIATED VASODILATATION, Indian Journal of Applied Research,Volume : 7 | Issue : 1 | JANUARY 2017


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