Volume : V, Issue : III, March - 2015

A Study on Herpes Simplex Virus Type–2 Specific seroprevalence among HIV positive Patients of a Tertiary Care Hospital in Central India

Dr. Nikita Sherwani, Dr. R. K. Khadse, Dr. Dhiraj Bhawnani

Abstract :

India has the third highest number of estimated people living with HIV in the world. The intricacy of interaction between HIV and herpes viruses at the cellular level and the possibility of adverse outcome leading to heightened activity of either virus with disease progression is an alarming situation. Hence knowledge about the co–existence of HIV with other viruses is not only essential but is mandatory to monitor the disease progression and more importantly in the treatment of these infections, where the specific therapy is identified and available. The current prospective study was conducted in the Department of Microbiology, Indira Gandhi Government Medical College and Mayo General Hospital, Nagpur, Maharashtra from August 2005 to August 2007.All the individuals who were positive for HIV infection were selected for this study and further tested for the presence of anti HSV–2 antibodies. Three hundred healthy age and sex matched HIV–negative controls for anti HSV–2 antibodies were also included in the study. Present study showed male preponderance in HIV positive patients. Anti–HSV2 antibodies could be detected in 43.6% HIV positive patients and in 17.33% HIV–negative controls. The difference in positivity of both viral agents studied in HIV positive patients was highly significant as compared to HIV–negative individuals (p < 0.001).This study concludes that the seroprevalence of HSV–2 antibodies is significantly higher among HIV– positive patients as compared to HIVnegative controls, also that the increased seroprevalence of HSV–2 antibodies is observed in persons who acquire HIV–I infection through heterosexual route. These findings suggest that HSV–2 type specific serological testing in the Indian HIV–infected subpopulation could be an efficient strategy to diagnose clinically asymptomatic HSV–2 infections and therefore to reduce the risk of HSV–2 and HIV sexual transmission by convenient prophylactic counseling against unprotected intercourse.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Nikita Sherwani, Dr. R. K. Khadse, Dr. Dhiraj Bhawnani A Study on Herpes Simplex Virus-2 Specific Seroprevalence Among Hiv Positive Patients of a Tertiary Care Hospital in Central India Indian Journal of Applied Research, Vol.5, Issue : 3 March 2015

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