Volume : VIII, Issue : VIII, August - 2018

A Study on protein target validation and functional annotation of Hypothetical protein for Shigella dysenteriae

K. Shrivastava, A. Shrivastava

Abstract :

 Significant developments have been made in the ground of biological and computer science in past few decades which can be utilized to develop biological data. The study was performed on Shigella dysenteriae (S.dysenteriae). Shigella has four types of species. S.dysenteriae is one of them which cause dysentery. It destroys immunity of Homo sapiens because the survival capacity affects all age groups and it most commonly spreads in new born child and travelers. There are many drugs available in the market but they are not much effective, so we intended to identify the innovative drug target which is efficient and effective in curing the disease. The whole analysis is based on comparative study in S.dysenteriae (Query sequence) and homosapiens by online software to achieve the target. Entire evaluation is based on few steps:– A) Comparative study between S. dysenteriae and Homo sapiens protein sequence. B) Functional annotation of the hypothetical protein, for which KEGG software was used, which can satisfy the process of validation of drug target and in retrieving protein sequences. Major work is to establish the functional annotation of the hypothetical sequences from some conserved domain database, and for novel medicine, the high confidence limit standards are always considered.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

K. Shrivastava, A. Shrivastava, A Study on protein target validation and functional annotation of Hypothetical protein for Shigella dysenteriae, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-8 | August-2018

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