A Study on Role of Immunotherapy (IVIG) in the Treatment of Neonatal Sepsis in a Tertiary Care Centre in Eastern Bihar.

Dr. Kishore Kumar Sinha; Dr. Vimal Kumar; Dr. Brajesh Kumar

Volume : IX, Issue : V, May - 2019

A Study on Role of Immunotherapy (IVIG) in the Treatment of Neonatal Sepsis in a Tertiary Care Centre in Eastern Bihar.

Dr. Kishore Kumar Sinha, Dr. Vimal Kumar, Dr. Brajesh Kumar

Abstract :

INTRODUCTION: Neonatal sepsis is a clinical syndrome characterised by systemic signs of infection accompanied by bacteraemia in the first month of life. Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. OBJECTIVES: The present study was conducted to evaluate the effect of intravenous immunoglobulin (IVIG) in neonatal sepsis in preterm babies. METHODS: The present study was conducted in the NICU of Jawahar Lal Nehru Medical College And Hospital, Bhagalpur, Bihar in which 100 newborn were enrolled for the study from Feuary 2018 to January 2019. We used a dosage regimen of 1g/kg/day of IVIG. In this study we had 100 patients with documented sepsis; 50 of them received antibiotics (controls) and 50 of them received antibiotic and IVIG as adjuvant therapy. Finally we compared the outcomes of both groups. RESULTS: In the present study, all septic newborns had positive blood cultures. The most common cause of sepsis in our study was Klebsiella (56% of control and 36% of case groups). In both groups we found 62% early onset sepsis. There was no statistically significant difference between mortality rate in two groups (52% VS 48% of case and control, P>0.05). CONCLUSION: In our study it was found that there was no significant decrease in mortality rate with IVIG therapy in neonatal sepsis.