A STUDY ON SEPSIS – CLINICAL AND BIOCHEMICAL PROFILE AND A CORRELATION STUDY

Dr. P Aparna Devi; Dr. Fahima Begam; Dr. N.Partha Sarathy; Dr. Kalapala Abhilash

Volume : VII, Issue : V, May - 2017

A STUDY ON SEPSIS – CLINICAL AND BIOCHEMICAL PROFILE AND A CORRELATION STUDY

Dr. P Aparna Devi, Dr. Fahima Begam, Dr. N. Partha Sarathy, Dr. Kalapala Abhilash

Abstract :

Background: Septic response is a leading contributory factor for morbidity and mortality especially in intensive care settings. Recent data suggests that the incidence of sepsis worldwide is on the rise and at the same time the mortality rate remained high despite the ongoing advances in the management of sepsis. Objectives: To study the pattern and outcome of the patients with sepsis. To grade the patients with sepsis based on consensus conference criteria–sepsis, severe sepsis and septic shock and study each grade of sepsis within the group of patients. To find the occurrence of positive blood culture among the different grades of sepsis. To assess the type of organ dysfunction commonly encountered.To evaluate the outcome during the hospital stay. Methods: It’s a Prospective study, 50 subjects were recruited from ASRAM MEDICAL COLLEGE AND HOSPITAL MEDICAL INTENSIVE CARE UNIT in the department of general medicinewho fulfill the criteria for sepsis according to consensus conference criteria i.e. systemic inflammatory response syndrome caused by infection as underlying etiology (or) at least clinical evidence of infection. Thestudy was approved by institutional ethical committee. A written informed consent was taken from all the patients. Blood sample for bacterial culture / sensitivity was collected and sent soon after a diagnosis is made. Results: The incidence of the disease in our study group was found to be high in elderly patients between 65–74 year age group with predominant involvement of 74% males and 26% females, with a mean age of 54.68 years.40%were diagnosed to have sepsis,44%had severe sepsis and 16% with septic shock.The mortality rate is nil for sepsis to 31.8% in severe sepsis and 75% inpatients with septic shock. Overall mortality of 26% in our patients at the end of 28 days of follow up from the date of diagnosis of sepsis Conclusion: The prognosis was good in initial stages of sepsis, but was grave with septic shock (75% mortality). Hence early recognition and prompt management of sepsis is of paramount importance.