A STUDY ON THE INCIDENCE OF STRESS HAZARDS RELATIVE TO ALLOSTATIC LOAD AMONG HEALTHY VOLUNTEER IN INDIA

Abhilash Thomas; Jagadeesh G. Hiremath; Poornajith KM; Malay Kumar Samanta

Volume : VII, Issue : X, October - 2017

A STUDY ON THE INCIDENCE OF STRESS HAZARDS RELATIVE TO ALLOSTATIC LOAD AMONG HEALTHY VOLUNTEER IN INDIA

Abhilash Thomas, Jagadeesh G. Hiremath, Poornajith Km, Malay Kumar Samanta

Abstract :

Introduction: The objective of this study was to assess the stress hazards in respective to Allostatic load factors in Indian human volunteers. The benefits of establishing the relation of Allostatic load and vital body physiological functions would be helpful in measuring drug effectiveness. Methods: The Perceived Stress Scale 10 (PSS 10) was used to measure the stress levels. The Allostatic load factors such as Epinephrine, Norepinephrine, Dopamine and Cortisol were measured from urine and serum samples. The physiological vitals like blood pressure (BP), heart rate (HR), respiratory rate (RR) and body temperature were also measured manually. Results: The Allostatic load factors were found to be elevated with increased stress. The primary mediators of Allostatic; Epinephrine, Norepinephrine and Cortisol were elevated (p<0.05) with increased stress while Dopamine changes were little. The secondary mediators systolic blood pressure (134.17±5.15, p<0.05) and diastolic blood pressure (87.54±8.67, p<0.05) were high. The heart rate and respiratory rate were increased but body temperature had not altered. Conclusion: The Allostatic load factors can be used as better predictors of altered physiological functions. This shall be extrapolated to rate of drug metabolism during stress exposure. The study recommends further studies with repeated samples to prove this hypothesis.