Volume : VIII, Issue : III, March - 2018

A STUDY TO COMPARE THE EFFICACY OF DEXMEDETOMIDINE AND MIDAZOLAM FOR SEDATION IN CRITICALLY ILL PATIENTS IN INTENSIVE CARE UNIT.

Dr Karthik Shivani Lokeshappa, Dr Shashank Maladkar, Dr Shivananda Pt

Abstract :

 

Background

     Sedation forms an integral part of management of critically ill patients in ICU. Sedatives are used routinely in all ICU’s throughout the world. For decades, Gama aminobutyric acid (GABA) receptor agonists (including propofol and benzodiazepines such as midazolam) were used as sedative drugs for ICU patients Worldwide. Dexmedetomidine is an alpha–2A adrenoreceptor agonist, providing sedation and anxiolysis. In addition to sedation, dexmedetomidine provides analgesic effects, a lack of respiratory depression and may establish a more natural sleep–like state. Midazolam is selected as comparator owing to its frequent use in ICU for sedation.

Materials & Methods

     A prospective, double blinded, randomized trial was conducted in ICU of McGann hospital after taking permission from Institutional Ethical Committee. Study was done in 60 patients. They were randomly allocated into two groups. Group D – Dexmedetomidine (n=30) received Loading dose: 1microgm/kg Maintenance dose: 0.4microgm/kg/hr. Group M – Midazolam (n=30) Loading dose: 0.05mg/kg, Maintenance dose: 0.06mg/kg/hr. Hemodynamic variables, Richmond Agitation and Sedation Scale (RASS) were recorded. All data were represented as mean±  SD. Statistical analysis was done with SPSS version 21.0.

Results

Hemodynamic variables & sedation scores were better in Group D than in group M & were statistically significant. There were no major adverse effects in both the groups.

Conclusion

This study (which incorporated best sedation practices including a light–to– moderate

sedation level and daily arousal assessments in both study groups) showed no difference

in the time patients spent within the target sedation, however dexmedetomidine has

provided better hemodynamic stability and reduced development of delirium

and also cause resolution of delirium

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Karthik Shivani Lokeshappa, Dr Shashank Maladkar, Dr Shivananda PT, A STUDY TO COMPARE THE EFFICACY OF DEXMEDETOMIDINE AND MIDAZOLAM FOR SEDATION IN CRITICALLY ILL PATIENTS IN INTENSIVE CARE UNIT., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018

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