Volume : IX, Issue : IV, April - 2019

ACUTE AND CHRONIC TOXICITY STUDY OF SIDDHA HERBAL FORMULATION NELLI KUDINEER SAMULAM

Sumayya. M, Manoharan. A

Abstract :

Background: The Plant (Herb) is still considered among the important source of bioactive compound, especially in Siddha medicine that has been used for long peroids. The Nelli Kudineer (NK) has been mentioned in classical Siddha literature GunapadamMooligaiVaguppu(Murugesu Mudaliyar C.S,2013)(1) for the management of Rathamoolam (Shanmugavelu.K.N.,2003)(2) and it has been correlated symptoms in modern medicine is Bleeding Haemorrhoids. Objective: The objective of this study was to investigate the acute and Chronic toxicity of Siddha herbal formulation Nelli Kudineer (Samulam). Method: Acute toxicity and chronic toxicity of Nelli Kudineer (NK) is carried out as per the OECD–423 guidelines. In the acute toxicity study were used in female albino Wister rats, single and multiple enteral dose (60,300,2000 mg/kg) for 14 days administered all group of treated animals. At the end of the study, the trail animals are sacrificed and results were recorded. Results: The results are assessed for the effect of Nelli Kudineer. Animals body weight, relative organ changes, haematological, biochemical and histopathological parameters showed good progress. In the acute and chronic toxicity studies no mortality or behavioural changes were observed in treated rats used in Nelli Kudineer (2000 mg/kg) indicating that the LD 50 was less than Value is P 0.05. Conclusion: These results exhibit the absence of acute and chronic toxicity after treatment of Nelli Kudineer was observed. So, all the results were revealed NK is safer and high therapeutic uses in long period.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ACUTE AND CHRONIC TOXICITY STUDY OF SIDDHA HERBAL FORMULATION NELLI KUDINEER SAMULAM, Sumayya.M, Manoharan.A INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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