Acute kidney injury in pediatric patients with sepsis

Amit Gupta; Anil Rawat

Volume : VI, Issue : XII, December - 2016

Acute kidney injury in pediatric patients with sepsis

Amit Gupta, Anil Rawat

Abstract :

 Background: Acute kidney injury has been less extensively studied in the pediatric population. Most of the studies are limited to critically ill children admitted to the Pediatric Intensive Care Unit. Aim: The current study was undertaken to study the clinical profile of paediatric patients with sepsis with acute kidney injury, admitted to a tertiary care teaching hospital. Methods: It was a prospective, observational study done over a duration of 12 months (April 2015 – March 2016). Patients having sepsis with acute kidney injury were enrolled in the study. Data were recorded in a pre–formed, standardized pro forma and analysed using the software Epi–info version 7.1.5. Results: A total number of 350 patients with sepsis were admitted during the study period, of whom 120 (34.2%) patients who developed AKI, were included in the study. The mean age of presentation was 3.5 years (Range 1–6 years). Most common underlying single diagnosis for sepsis was pneumonia (66%), followed by acute gastroenteritis (56%), bacteremia (55.2%), urinary tract infections (35%), skin and soft tissue infections (12.6%). A mixed etiology was seen in 73.5% cases. AKI was associated with Multi organ dysfunction syndrome in 31.3% patients. A total of 107 (89.1%) patients improved and were discharged. Mean duration of hospital stay was 18 days (Range 7–29 days). Conclusion: AKI is not uncommon in pediatric patients with sepsis. Most common etiology for sepsis wass a mixed one and the most common single etiological diagnosis was pneumonia