Volume : VI, Issue : VII, July - 2016

Allopurinol Treatment Reduces Proteinuria in Patients with Type II Diabetes Mellitus

Zheni Gjergji

Abstract :

 BACKGROUND – Diabetic patients go through several stages of renal disease, moving from normo– to micro– to macroalbuminuria. Diabetic nephropathy is the main reason leading to end–stage renal disease. Incidence of diabetic nephropathy is approximately 20% to 30% of diabetic patients are affected by nephropathy, 15 years after the beginning of DM.1 Besides factors such as angiotensin II, cytokines, and vascular endothelial growth factor, uric acid may play a role as the underlying cause of diabetic nephropathy. OBJECTIVE – We evaluated allopurinol effects on proteinuria in diabetic patients with nephropathy. MATERIAL AND METHODS – 80 patients with type 2 diabetes mellitus and diabetic nephropathy (proteinuria, at least 500 mg/24 h and a serum creatinine level less than 3 mg/dL) were recruiting. 40 patients were randomized to receive allopurinol (100 mg/d) and 40 were randomized to receive placebo. Administration of antihypertensive and renoprotective drugs (angiotensin–converting enzyme inhibitors and angiotensin receptor blockers continued for both groups, without changes in dosage. Proteinuria was compared at baseline 2 and 4 months between the two groups. RESULTS – Each group consisted of 19 men and 21 women. Serum levels of uric acid (P = .02) and 24–hour urine protein (P = .049) were significantly lower in the patients on allopurinol treatment, after 4 months compared with the control group. CONCLUSIONS – Allopurinol (low dose) can reduce severity of proteinuria after 4 months of drug administration, which is probably due to decreasing the serum level of uric acid. Thus, allopurinol can be administered as an adjuvant cost–effective therapy for patients with diabetic nephropathy

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Zheni Gjergji Allopurinol Treatment Reduces Proteinuria in Patients with Type II Diabetes Mellitus Indian Journal of Applied Research,Volume : 6 | Issue : 7 | July 2016

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