ALTERATIONS OF ANTIOXIDANT ENZYME LEVELS AND OXIDATIVE STRESS MARKER IN LIVER AND SKELETAL MUSCLE DURING AGING.

Madhuri Mehta; N K Gupta

Volume : VIII, Issue : VIII, August - 2018

ALTERATIONS OF ANTIOXIDANT ENZYME LEVELS AND OXIDATIVE STRESS MARKER IN LIVER AND SKELETAL MUSCLE DURING AGING.

Madhuri Mehta, N K Gupta

Abstract :

The aging process has been described by various theories, but, the free radical theory of aging has received widespread attention. The present study was carried out to study the influence of aging on antioxidant enzymes; Superoxide Dismutase (SOD), Catalase (CAT) and oxidative stress marker expressed as thiobarbituric acid reactive substances (TBARS;MDA) in the liver and skeletal muscle (Gastrocnemius) of Swiss albino mice at different age intervals (0 day–6 months). The antioxidant enzyme levels were decreased in moderately aged mice when compared to young mice in both tissues. In liver, no definite trend in the levels of MDA was observed however in skeletal muscle an age dependent decrease was observed in early stages. Our study suggests that free radicals could be the causative agents of aging process in which antioxidant enzymes have a definite regulatory contribution.