Ameliorative role of SAC and berberine against DEN+CCl4 induced hepatocarcinoma

Dipanwita Sengupta; Avik Sarkar; Soumosish Paul; Kaustav Dutta Chowdhury; Pradip Kumar Sur; Gobinda Chandra Sadhukhan

Volume : V, Issue : V, May - 2015

Ameliorative role of SAC and berberine against DEN+CCl4 induced hepatocarcinoma

Dipanwita Sengupta, Avik Sarkar, Soumosish Paul, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan

Abstract :

Male swiss albino mice were exposed for 90 days to diethylnitrosamine and carbon tetra chloride to develop environmentally available carcinogenic chemical induced hepatocarcinoma. DEN+CCl4 exposed&nbsp; group were treated with 8mg/kg body weight berberine and 250mg/kg body weight SAC in individual and as well as&nbsp; in combination to determine the efficacy in the amelioration of liver tissue carcinoma. After 30 and 60 days of drug&nbsp; treatment stress specific biochemical parameters such as ALT, AST, ALKP, GGT activities, TBARS content and histopathological tissue analysis were performed. Data evaluation portrayed effective removal of chemically induced hepatocarcinoma since activities of enzymatic biomarkers and histological liver tissue structure were similar to control animal&nbsp; after SAC and berberine combined treatment. &nbsp;