An assessment of HRV in female migraine patients  during headache free period

Durgavati Tak; Jyotsna shukla; Amitabh Dube; Bajrang Tak; Kapil dev Mathur

Volume : VI, Issue : X, October - 2016

An assessment of HRV in female migraine patients during headache free period

Durgavati Tak, Jyotsna Shukla, Amitabh Dube, Bajrang Tak, Kapil Dev Mathur

Abstract :

Background: Migraine is the 3rd most prevalent and 7th leading cause of disability worldwide. It is a chronic neurological disorder that has diverse autonomic manifestations. Yet, there are less conclusive studies available regarding dysfunctions of the autonomic nervous system in migraineurs during headache free periods. Objective: To assess and compare the HRV in female migraine patients during headache free period and age matched healthy female controls. Material and Methods: Forty diagnosed female migraine patients age ranging between 30–40years, fulfilling the criterias of ICHD 2004 formed the study group. Age matched 40 healthy female subjects froms SMS Medical College were taken as control. The assessment of Heart Rate Variability was done by recording the 5 minutes E.C.G.by RMS ECG machine The analogue ECG signals were converted to digital signal and stored in the computer for offline Frequency Domain analysis. Statistical analysis was performed using SPSS software version 20 and unpaired student t–test to derive the level of significance. Results: The mean of HF n.u. in % in migraine patients was 37.95±8.54 and of controls subjects was 63.48±3.37. ( pvalue 0.000) The mean of LF n.u.in % in migraine patients was 62.05±8.54 and of control subjects was 36.52±3.37. (p–value 0.000) The mean of LF/HF ratio of migraine patients was 1.77±0.59 and of control subjects was 0.58±0.08. (p–value 0.000) Conclusion: Migraineurs during headache–free periods are found to have sympathetic hyperactivity. Therefore, an early understanding of the autonomic nervous system dysfunctions in migraine patients can help in diagnosis, prevention and treatment