An Evaluation and comparison of the various preparations of intravenous injection, Transdermal patch and rectal suppository of diclofenac sodium in the pain management after gynaecological surgery: A randomized trial

Dr Rajiv Ratan Singh Yadav; Dr Vipin Kumar Singh; Dr Shiv Shanker Tripathi; Dr Sachin Avasthi; Dr Pushkar Ranjan

Volume : VI, Issue : III, March - 2016

An Evaluation and comparison of the various preparations of intravenous injection, Transdermal patch and rectal suppository of diclofenac sodium in the pain management after gynaecological surgery: A randomized trial

Dr Rajiv Ratan Singh Yadav, Dr Vipin Kumar Singh, Dr Shiv Shanker Tripathi, Dr Sachin Avasthi, Dr Pushkar Ranjan

Abstract :

Objective: To evaluate and compare the various preparations of intravenous injection, Transdermal patch and rectal suppository of diclofenac sodium in the pain management after gynaecological surgery. Methods: This study was a randomized clinical trial. Hundred ASA grade I female patients between 18–70 years of age scheduled for major gynaecological surgery were included in the study divided in four groups (25 patients in each group). Group I received 100 mg rectal suppository of diclofenac, Group II receive 200 mg rectal suppository of diclofenac, Group III receive 75 mg intravenous injection diclofenac and Group IV received 200 mg transdermal dermal patch of diclofenac. Results: The baseline data was comparable among the groups. There was significant difference in the hemodynamic parameters after post–op and subsequent time intervals. However, minor difference was observed among the groups in serum creatinine and hemoglobin. Nausea was observed to be higher in Group I & II than Group III & IV. However, vomiting was lower in Group III than Group I, II and IV. Conclusion: In country like India where the anti narcotic act very much prevalent, the NASAID (like Transdermal patch and rectal suppository of diclofenac) are best drugs for postoperative pain control.