An observational cross-sectional study to estimate use of Modafinil /Armodafinil in patients attending Psychiatry OPD of Tertiary care Hospital in central India

Dr. Pravin R. Verma; Dr. Lokeshkumar G. Chirwatkar; Dr. Shushma Sonawane

Volume : X, Issue : VIII, August - 2020

An observational cross-sectional study to estimate use of Modafinil /Armodafinil in patients attending Psychiatry OPD of Tertiary care Hospital in central India

Dr. Pravin R. Verma, Dr. Lokeshkumar G. Chirwatkar, Dr. Shushma Sonawane

Abstract :

Background:– Psychiatric patients frequently complains of daytime drowsiness, weakness, lethargy, fatigue due to various psychotropic medications or due to underlying psychopathology. This not only severely impair productivity and performance, but may also have detrimental effects on social functioning and overall quality of life. Modafinil/armodafinil is an effective medication that can be used to overcome these complains. Material and Method:– An observational cross–sectional study was done at a tertiary care hospital by randomly selecting l11 patients following up in psychiatry opd who were on modafinil/armodafinil for various indications. Specially prepared proforma to collect information including socio–demographic aspects, clinical profile were obtained. Patients were evaluated by using clinical global impression scale,data was pooled, tabulated and statistical analysis was done in terms of frequency and percentage. Result :– Study showed majority of participants were young, in age group of 21–35 yrs n= 45(40.54). with an average of 40.97 years having average 9.91 years of schooling and average per capita income of 2647.30 rupees. The clinical profile of participants showed majority involvement of patients with schizophrenia n=62 (55.86%) mainly receiving modafinil n=86 (77.48%) at a maximum dosage of 100mg, n= 71 (63.97) used for excessive daytime sedation n= 79 ( 71.17%). Mean % of improvement of 76 was found and 93.7% participants did not show any side effect to use of modafinil/armodafinil. Conslusion :– Modafinil/armodafinil is a safe and effective alternative to improve quality of life of patients attending psychiatric OPD with various diagnostic indications Modafinil used in dose of 100 mg for atleast 3months showed more than 70% improvement in drowsiness, fatigue, lethargy like symptoms. Around 97% respondent reported no side effects and minor side effects were successfully treated symptomatically.