An observational study of haemodynamic stress responses to endotracheal intubation and post-operative sedation with intravenous dexmedetomidine: A comparison between two doses.

Dr Mona V. Bilandani; Dr Deepshikha; Dr Kiran B. Patel; Dr.Navya R. Thota; Dr Ravina N. Vinchhi

Volume : VIII, Issue : XII, December - 2018

An observational study of haemodynamic stress responses to endotracheal intubation and post-operative sedation with intravenous dexmedetomidine: A comparison between two doses.

Dr Mona V. Bilandani, Dr Deepshikha, Dr Kiran B. Patel, Dr. Navya R. Thota, Dr Ravina N. Vinchhi

Abstract :

Introduction Dexmedetomidine, blunts sympathetic response to laryngoscopy and tracheal intubation for patients requiring general anaesthesia. Aims and Objectives To study the efficacy of dexmedetomidine in blunting of hemodynamic responses for intubation and post–operative sedation. Methodology Sixty patients between 18–65 years of age requiring general anaesthesia were selected randomly and divided in 2 groups (30 in each group). Group A was given the dexmedetomidine at the dose of 0.5 mcg/kg and group B was given the dexmedetomidine at the dose of 0.75 mcg/kg in 100 ml NS infused over 10 minutes. The hemodynamic stress response was assessed at 1, 3, 5 minutes after intubation; also post–operative sedation up to 4 hours was noted. Discussion Following intubation the hemodynamic response starts within few seconds, reaches its peak at 1–2 minutes; and returns to its baseline level at 5 minutes. Dexmedetomidine act through α–2 receptor agonist in locus caeruleus, the predominant nor adrenergic nuclei of upper ainstem. Conclusion: We conclude that preoperative infusion of dexmedetomidine at the dose of 0.75 mcg/kg shows better response to blunting of stress responses. Also the post–operative sedation was not significant with any group.