AN OBSERVATIONAL STUDY TO COMPARE LOW DOSE ESMOLOL AND LOW DOSE LABETALOL FOR ATTENUATION OF SYMPATHOMIMETIC RESPONSE TO LARYNGOSCOPY AND INTUBATION

Singla Priyanka R.; Chauhan Dinesh

Volume : VIII, Issue : II, February - 2018

AN OBSERVATIONAL STUDY TO COMPARE LOW DOSE ESMOLOL AND LOW DOSE LABETALOL FOR ATTENUATION OF SYMPATHOMIMETIC RESPONSE TO LARYNGOSCOPY AND INTUBATION

Singla Priyanka R. , Chauhan Dinesh

Abstract :

Laryngoscopy and endotracheal intubation are associated with cardiovascular & neurological changes. Studies compå esmolol with labetalol to attenuate pressor response are lacking.

AIM:

To compare the effects of low doses of esmolol and labetalol for attenuation of sympathomimetic response to laryngoscopy and intubation.

METHODS:

Study Design: Observational study

Study Site: Dhiraj Hospital,Piparia

Study Duration: 1year

Study Population: After ethical committee’s approval, this study was carried out on 60 patients, randomly and equally allocated to any of the two groups using chit method.

HR,SBP,DBP,MAP,RPP&ECG changes were recorded prior to induction, at–intubation and 1,3,5&10min post–intubation.

RESULTS:

Analysis showed no significant variation in HR,SBP&DBP at intubation for both the studied drugs but post–intubation analysis revealed lower HR,SBP,MAP&RPP in labetalol group(p<0.001).

CONCLUSION(s) :

The measurement of baseline and postintubation parameters revealed statistically significant variation in HR,SBP,MAP&RPP in Esmolol as compared to Labetalol thus proving our study.