Volume : IX, Issue : VII, July - 2019

Analysis of MLH1 and MSH2 immunohistochemistry in colorectal carcinomas

Dr. P. Pavethira, Dr. Suma. B. Pillai

Abstract :

The aim of this study is to determine the frequency of loss of mismatch repair protein MLH1 and MSH2 expression by immunohistochemical method in colorectal carcinomas.and to study is correlation with various clinical and histopathological characteristics so as to determine if there is any significant association between them.In our study population 40% of the cases lacked the expression of mismatch repair proteins MLH1 and MSH2 which is significantly high when compared to other studies done in Indian population. MMR protein expression statistically associated with histological type and grade of the tumor.MSH2 negative tumors were mostly poorly differentiated adenocarcinomas which included mucinous and signet ring cell carcinomas.Immunohistochemical method for mismatch repair proteins expression can be used as a screening method for detection of colorectal carcinoma with MSI.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ANALYSIS OF MLH1 AND MSH2 IMMUNOHISTOCHEMISTRY IN COLORECTAL CARCINOMAS, Dr.P.Pavethira, Dr.Suma.B.Pillai INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-7 | July-2019

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