Androgen Excess and Genetic Instabilities in Anovulatory Infertility

Arun William; Viji Krishnan; Deepthi T; Sreesha SR; Dinesh Roy D

Volume : VI, Issue : IV, April - 2016

Androgen Excess and Genetic Instabilities in Anovulatory Infertility

Arun William, Viji Krishnan, Deepthi T, Sreesha Sr, Dinesh Roy D

Abstract :

Anovulation is the failure of the ovaries to release ova over a period of time generally exceeding three months. Anovulation is one of the major causes of infertility. Among the causes of infertility, 20–25% accounts for anovulation. The present study was undertaken to evaluate the androgen excess and genetic instabilities in anovulatory infertility by investigating the various anthropometric and clinical aspects of the subjects. Twenty four subjects with anovulatory infertility and 19 healthy women without any chronic illness were involved in this study. Reproductive hormones namely leutinizing hormone (LH) and follicle stimulating hormone (FSH) were estimated in each subjects after obtaining their informed consent. Cytokinesis–block micronuclei (CBMN) assay was also carried out in the lymphocytes of the subjects to assess the somatic DNA damage. The study demonstrated that the micronuclei frequency significantly elevated in the study subjects than control subjects. Anovulatory women with various risk factors such as history of chronic illness, family history of cancer, increased duration of married life, endometriosis, hypercholesterolemia etc. can lead to increased genetic instabilities and the severity of infertility. Lifestyle management should be used as the primary therapy for the treatment of metabolic complications and improvement in ovulatory function and pregnancy