Volume : IX, Issue : I, January - 2019

Anti-inflammatory activity of Pterospermum acerifolium flower in Wistar rats.

Dr. Biswa Jyoti Bora

Abstract :

In vitro as well as in vivo studies on anti–inflammatory activity of the methanolic extract of Pterospermum acerifolium flower was investigated. In–vitro study was screened by Hyaluronidase Inhibition Assay and In–vivo was studied using carrageenan–induced rat paw oedema model in which indomethacin at 10 mg•kg–1 (standard) and methanolic extract of Pterospermum acerifolium flower (Test) at 200 mg•kg–1were administered orally to 18 Wistar rats 1 h before induction of oedema and compared with a negative control given 10 ml•kg–1 distill water. The results of in vitro study have shown that the flower is a highly potent inhibitor of hyaluronidase with 51.76% inhibition compared to 61.25% of Indomethacin at 1µg concentrations of the drugs respectively. The mean percentage inhibition of paw volume of rats treated with indomethacin was 91.1% followed by Pterospermum acerifolium treated group with 65.6%. These results suggest that Pterospermum acerifolium flower has anti–inflammatory property comparable with the standard drug and may be useful for the treatment of inflammatory conditions.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ANTI-INFLAMMATORY ACTIVITY OF PTEROSPERMUM ACERIFOLIUM FLOWER IN WISTAR RATS., Dr. Biswa Jyoti Bora INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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