Anti-MOG associated encephalitis masquerading as an acute manic episode responded to Rituximab.

Ritwik Ghosh; Arpan Mandal; Devlina Roy; Souvik Dubey; Mrinalkanti Ghosh

Volume : IX, Issue : II, February - 2019

Anti-MOG associated encephalitis masquerading as an acute manic episode responded to Rituximab.

Ritwik Ghosh, Arpan Mandal, Devlina Roy, Souvik Dubey, Mrinalkanti Ghosh

Abstract :

Myelin Oligodendrocyte Glycoprotein (MOG), encoded by MOG gene present in chromosome no. 6, is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic memanes helping in myelination of nerves and serves as an important adhesion molecule. In the last two decades many MOG–opathies have been discovered and enlisted in the category of inflammatory demyelinating diseases. Anti–MOG associated encephalitis has varied presentations. Seldom they present as neuropsychiatric syndromes and may be therefore misdiagnosed for a primary psychiatric illness. Again, this can be prevented with high index of suspicion, and accurate early diagnosis with proper serologic testing. And early institution of therapy is life–saving. We hereby report a case of anti–MOG encephalitis which presented with cardinal manifestations of an acute manic episode hiding the catastrophe underneath