Anti–TRA–Ab, Anti–TPO–Ab, and FT3 as a Biochemical Panel for Differential Diagnosis of Graves‘ Disease from Hyperthyroidism

Dr. Ghada A.Elfadil; Isam Eddin M Eltahir; Dr. Abdelgadir A. Elmugadam

Volume : IV, Issue : V, May - 2014

Anti–TRA–Ab, Anti–TPO–Ab, and FT3 as a Biochemical Panel for Differential Diagnosis of Graves‘ Disease from Hyperthyroidism

Dr. Ghada A. Elfadil, Isam Eddin M Eltahir, Dr. Abdelgadir A. Elmugadam

Abstract :

High titers of antibodies to anti thyrotropin receptor ( TRA–Ab), and thyroperoxidase (TPO–Ab) antibodies are the hallmarks of human autoimmune thyroid diseases. The aim of this study was to determine the titers of these antibodies in Sudanese Patients (mean age 33.22±10.04, range 19–59 years) with hyperthyroidism and graves disease. This study was done in order to investigate any correlation regarding clinical manifestations that may be unique to patients. One hundred Sudanese patients with hyperthyroidism(50with hyperthyroidism and clinically diagnosed with graves disease, 50 with hyperthyroidism and clinically diagnosed without graves disease), and fifty apparently healthy as control group , age and sex were matched. Study done in Endocrinology Outpatient Clinic at Omdurman Teaching Hospital, Khartoum state, Sudan, during the period June 2011 to June 2013. Thyroid function test ( FT3, FT4, and TSH) was determined by using fully automated chemical analyzer (ROCH ELECSYS ) with COBAS kits, and anti thyroperoxidase antibodies, and anti thyrotropin receptor antibodies were determined by ELISA technique with Euro immune Kits. Analysis of the data was performed using the Chi–square test with P< 0.05 considered significant. Study showed that there were significantly high serum FT3, anti TRA, TPO antibodies among the Sudanese patients with Graves disease compared with patients with hyperthyroidism. 90% of patients with graves disease had positive TRA antibodies, and 16% had positive TPO antibodies.Conclusion: In conclusion, the parameters, FT3, anti–TRA– Ab, and anti–TPO–Ab can be used as a biochemical panel for differential diagnosis of Graves disease from hyperthyroidism