ANTI–HYPERLIPIDEMIC ACTIVITY OF THE BARK EXTRACT OF TERMINALIA ARJUNA IN CAFFEINE INDUCED MICE

P.SenthamilSelvan; S.Velavan; P.Sagunthala; Shyama Subramanian

Volume : V, Issue : VIII, August - 2015

ANTI–HYPERLIPIDEMIC ACTIVITY OF THE BARK EXTRACT OF TERMINALIA ARJUNA IN CAFFEINE INDUCED MICE

P. Senthamilselvan, S. Velavan, P. Sagunthala, Shyama Subramanian

Abstract :

<p>&nbsp; The present study was aimed to investigate the effect of bark extract Terminalia Arjuna (2.4g/kg of body weight) on caffeine (150 mg/kg body weight) induced coronary heart disease. Male Swiss albino mice weighing about 20 and 22g were used as the experimental animal for the study. Caffeine dissolved in physiological saline (NaCl) with a pH of 7.0 administered orally to Swiss albino mice continuously for about 14 days. Thereafter, all the animals sacrificed and the blood sample is collected for all groups. The samples were estimated quantitative examinations of Low density lipoprotein cholesterol, Very low density lipoprotein cholesterol, High density lipoprotein cholesterol, triglyceride and Total cholesterol. That the values are compared against with Terminalia Arjuna treated animals. All the animals at the end of experiment showed significant elevation in the level of cholesterol, LDL&ndash;cholesterol, VLDL&ndash;cholesterol and triglycerides and also a decrease level of HDL&ndash;cholesterol (p&lt;0.001). These finding suggest that the bark extract of Terminalia Arjuna has protective effects against caffeine induced coronary heart disease and may have potential as a cardio protective agent.</p>