Antiangiogenic activity of aqueous flower extracts of Aster, Calendula and Gerbera plants

Mrs. Suman Satyarum; Dr. Mrs. Padma V. Deshmukh

Volume : IX, Issue : VIII, August - 2019

Antiangiogenic activity of aqueous flower extracts of Aster, Calendula and Gerbera plants

Mrs. Suman Satyarum, Dr. Mrs. Padma V. Deshmukh

Abstract :

Angiogenesis is the formation of new blood vessels form pre–existing vessels. Inhibition of angiogenesis is considered to be an important strategy for cancer therapy. Antiangiogenic activity of crude aqueous flower extracts of Callistephus chinensis, Calendula officinalis and Gerbera jamesonii were assessed using in vivo CAM assay. All three plants are from Asteraceae family, an aromatic annual herb, which is used in traditional system of medicine to treat various diseases like anti–inflammatory, antispasmodic and antitumor activity. Phytochemical analysis of the plant extracts was done by TLC. They are rich in Flavanoids, Alkaloids and Glycosides. Aster and Calendula showed maximum inhibition of blood vessels formation as compared to Gerbera. The number of blood vessels formed is (23.83, 24.66 and 30.33) respectively. All three plants extract inhibited angiogenesis by blocking normal vascularisation as compared to normal at 50 mcg/ml concentration. Sorafinib is used as positive anti–angiogenic drug control.