Volume : V, Issue : IV, April - 2015
Anticancer Activity From The Leaf Acetone Extract of Piper Betle Using Human Lung Cancer Cell Line (A549)
N. Padmapriya, T. V. Poonguzhali
Abstract :
Piper betle Linn. commonly known as paan in India belongs to family Piperaceae. The leaves are used
for treating cough, foul smell in mouth, ozoena, onchitis, clear throat and stypne. Lot of research work
has been carried out on antibacterial, antiprotozoan, antifungal, antioxidant, immunomodulatory, antimutagenic, antileishmanial, neurostimulatory properties of piper betle leaves. However not much data is available on the antitumor
properties and their derivatives.
SUMMARY
The present study was undertaken to check the antiproliferative activity from the leaves of acetone extract of Piper betle using human lung cancer cell line (A549). The leaves of P. betle was identified in and around Guindy. Fresh leaves
were further processed for extract preparation. Lung cancer cell line (A549) was obtained from NCCS, Pune and was
maintained in minimum essential media supplemented with 10% FBS, Pencillin (100U/mL) and streptomycin (100µg/mL)
in humidified atmosphere of 5% CO2 at 37°C. IC50 values represented the maximum activity. An increasedrate of cell
death was significantly observed with increase in concentration of leaf extract irrespective of the cell type.
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DOI : 10.36106/ijar
Cite This Article:
N. PadmaPriya, T.V. Poonguzhali Anticancer Activity From The Leaf Acetone Extract of Piper Betle Using Human Lung Cancer Cell Line (A549) Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
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N. PadmaPriya, T.V. Poonguzhali Anticancer Activity From The Leaf Acetone Extract of Piper Betle Using Human Lung Cancer Cell Line (A549) Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
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