Volume : V, Issue : I, January - 2015

Antihyperglycemic effect of p–Coumaric acid on Streptozotocin induced Diabetic Rats

V. Amalan, N. Vijayakumar

Abstract :

The present study was to investigate the possible protective effects of p–coumaric acid against streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced in male albino Wistar rats by a single dose of STZ intraperitoneally 40 mg/kg b.w. and treated 30 days with p–coumaric acid (100 mg/kg b.w.). Body weight, glucose, insulin, hemoglobin (Hb), glycosylated hemoglobin (HbA1C), lipid peroxidation products and enzymic antioxidants were investigated. Administration of p–coumaric acid showed significant decreased fasting blood glucose and increased insulin level as compared with diabetic rats. The treatment also results in significantly increased levels of Hb and decreased HbA1C. The activities of enzymes antioxidant increased by the administration of p–coumaric acid in liver and kidney tissues of diabetic rats. The overall results suggest that p–coumaric acid may effectively possess potential antihyperglycemic and antioxidant activity in STZ–induced diabetic rats by scavenging of free radicals and reducing the risk of diabetic complications.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

V. Amalan,N. Vijayakumar Antihyperglycemic effect of p-Coumaric acid on Streptozotocin induced Diabetic Rats Indian Journal of Applied Research, Vol.5, Issue : 1 January 2015

Number of Downloads : 846

References :