Antimicrobial Resistance in Systemic Lupus Erythematosus with Infection at RSUP. H. Adam Malik Medan

Blondina Marpaung; Joshua Patrick; OK Moehad Sjah

Volume : VIII, Issue : VIII, August - 2018

Antimicrobial Resistance in Systemic Lupus Erythematosus with Infection at RSUP. H. Adam Malik Medan

Blondina Marpaung, Joshua Patrick, Ok Moehad Sjah

Abstract :

Introduction. The main causes of death in SLE patients are major organ failure caused by infection, active disease and cardiovascular disease where in the last decades, the leading cause of death in SLE patients has changed from active disease to infection. SLE patients have a high risk of infection due to impaired intrinsic immune responses, immunosuppressant drug use and complications of vital organs from SLE disease. The still limited data on antimicrobial resistance patterns in SLE patients in Indonesia is the basis for this study. The purpose of this study was to investigate antibiotic resistance in SLE patients with infection at RSUP Haji Adam Malik Medan. Methods. Descriptive study was conducted at Adam Malik General Hospital Medan in January 2014 to December 2017. Data obtained through medical record at RSUP H. Adam Malik. Infection in SLE patients was based on positive culture results according to focal infection. Result. Patients with SLE infection were 122 with the most sex was female (91,8%) and mean age 32,08 + 11,1 year. The most infection sites were in the lungs (50.4%) and urinary tract (29.8%). Most microorganisms were Escherichia coli (26.7%) and Klebsiella pneumonia (22.9%). Ampicillin, Norfloxaxin, Doxycycline, and Clindamycin are the most resistant antimicrobials in SLE patients with resistance values> 70%. Conclusion. Escherichia coli and Klebsiella pneumonia are the most common microorganisms found in SLE patients with infections at RSUP H. Adam Malik Medan. Resistant antimicrobials in SLE patients are Ampicillin, Norfloxaxin, Doxycycline, and Clindamycin.