Antimicrobial Usage Pattern and Outcome of Neonatal Sepsis in Sick Newborn Care Unit of a Tertiary Care Teaching Hospital of Odisha

Dr. Paramita Parida; Dr. Rajlaxmi Upadhyay; Dr. Sabita Mohapatra; Jnanindra nath Behera; Sagar Parida; Manas Ranjan Upadhyay

Volume : X, Issue : VII, July - 2020

Antimicrobial Usage Pattern and Outcome of Neonatal Sepsis in Sick Newborn Care Unit of a Tertiary Care Teaching Hospital of Odisha

Dr. Paramita Parida, Dr. Rajlaxmi Upadhyay, Dr. Sabita Mohapatra, Jnanindra Nath Behera, Sagar Parida, Manas Ranjan Upadhyay

Abstract :

Background: Neonatal sepsis (NS) has been a major cause for mortality, morbidity in neonates of developing countries. It demands prompt diagnosis and treatment. Antimicrobials form the mainstay of treatment in NS. Standard treatment guidelines of Odisha 2018 for antimicrobial use in infectious diseaser have paved the way for rationalizing antibiotic use, but it needs tailoring according to the prevalent local microbiota and individual patient needs. A periodic surveillance of the microbial etiology and antimicrobial resistance pattern in NS can be useful in rational selection of empirical antimicrobial therapy. Aim & Objectives: Hence this study was designed to analyze utilization pattern of antimicrobial agents in neonatal sepsis and its outcome in SNCU of a tertiary care teaching hospital of Odisha. Method: A prospective observational study was carried out for 6 months on patients of neonatal sepsis admitted to Sick Newborn Care Unit. Data regarding demographic parameters and antimicrobial utilization pattern were collected through a predesigned case record form. Antimicrobial usage quantified as days of therapy (DOT) per 100 patient days. The duration of hospital stay, and final outcome of treatment were assessed. Results: Majority of antimicrobials prescribed in NS were on empirical basis with ampicillin, gentamicin and amikacin in descending order of DOT. There were majority injection prescribed in generic name from EDL. Case fatality rate was 2%. Conclusion: There is need of Antibiotic stewardship and standard treatment guidelines to promote rational use of antimicrobials in NS in our hospital.