Antioxidant and Anti–Inflammatory Potency of  Mesua Ferrea Linn

Dr.Manjunatha B.K; Syed Murthuza; Divakara R; M. Archana; R. J. Sarvani; Steffina Varghese; Kusum Paul

Volume : III, Issue : VIII, August - 2013

Antioxidant and Anti–Inflammatory Potency of Mesua Ferrea Linn

Dr. Manjunatha B. K, Syed Murthuza, Divakara R, M. Archana, R. J. Sarvani, Steffina Varghese, Kusum Paul

Abstract :

The present study was conducted to evaluate antioxidant and anti–inflammatory potency of stem bark of Mesua ferrea L. an ethno medicinally important plant. Evaluation of in vitro antioxidant activity was carried out by Total antioxidant, DPPH, Ferric reducing, ABTS and nitric oxide assays. In vitro anti–inflammatory assays was also studied through inhibition of HRBCs memane stabilization, heat induced hemolysis, Proteinase inhibitory activity and albumin denaturation assay. Results revealed that the methanolic extracts have significantly higher antioxidant activity scavenging for DPPH assay (89.70%), ABTS assay (77.64%), and Nitric oxide scavenging 89.28%. Total phenolics–content found to be 33,600 mg/100g plant material, total flavonoids 164 µg/ml and total tannins content 156 µg/ml were significantly higher in methanol extract. The methanol extract of the plant exhibited significant anti–inflammatory activity for HRBCs memane stabilization (78.20%), heat induced hemolysis (47.40%), Albumin Denaturation (70.58%) and for Proteinase inhibitory activity (50.73%).