Volume : III, Issue : X, October - 2013

Antioxidant and Antibacterial Activity of Some Newer Flavone Derivatives

Jayashree B. S, Piyush Chaturvedi, Venkatachalam H

Abstract :

Synthesis of novel chalcone from the 2–hydroxy acetophenone and 5–nitro thiophene carboxyaldehyde with various substitutions are described. They were evaluated for their antioxidant and antibacterial activity against Gram positive and Gram negative bacteria. The test compound JPC–9 is one of the test compounds with highest IC50 values by DPPH and ABTS method and has shown log P value at 1.76 against standard ascorbic acid. Compounds such as JPC–3, JPC–4, JPC–5, JPC–6, JPC–9, JPC–10, and JPC–13 were found to have shown zone of inhibition against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa and Escherichia coli at the range 31.25–250 µg/50µL when compared to that of the standard ciprofloxacin at 25µg/50µL.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Jayashree B. S, Venkatachalam H / Antioxidant and Antibacterial Activity of Some Newer Flavone Derivatives / Indian Journal of Applied Research, Vol.3, Issue.10 October 2013

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