Volume : III, Issue : VII, July - 2014

ANTIOXIDANT AND ANTICHOLESTEROL ACTIVITIES OF MORINDA CITRIFOLIA L. LINN IN RATS

Dr. Shailesh Tawade, Dr. Rohini Sivabalan

Abstract :

Plants are potential sources of natural antioxidants. Herbal and natural products have been used for centuries, throughout the world, in every culture. Natural antioxidants are widely used because they are safe and cause less adverse reactions. Morinda citrifolia L. commonly known as Noni from the family Rubiaceae is a plant typically found in Hawaii, Tahiti, tropical Asia, and southern Taiwan. It can be used as a raw material for nutraceutical and functional food products. Various parts of the plant, including the roots, stems, leaves and fruit have been consumed solely on the basis of the assumption that it possesses healing properties. However, it has never been scientifically proven that Morinda citrifolia L has the ability to cure these illnesses. Many In vitro and In vivo antioxidant studies of Morinda citrifolia L leaf showed that it possess antioxidant property.

In vitro antioxidant study of fruit extract showed very low antioxidant potential.               In the present study we have evaluated anti oxidant and antihyperlipidemic activity of Morinda citrifolia L fruit extract in rat. For antioxidant study fruit extract was administered at the dose of 500 mg/kg and 1000 mg/kg by oral route in rats for 8 weeks. Result of this study showed that there is non significant increased in SOD in male rats whereas significant increased in SOD value in female rats treated with 1000 mg/kg of fruit extract as compared to control. There is significant decreased in lipid peroxidation activity in both male and female groups treated with 500 mg/kg and 1000 mg/kg of fruit extract as compared to control. Significant increased in SOD and reduction in lipid peroxidation suggests that extract has antioxidant property. In the antihyperlipidemic study Morinda citrifolia L fruit extract was administered in triton WR – 1339 induced hyperlipidemic rats at the dose of 1000 mg/kg at 24 hrs treatment and lipid profile results were compared with hyperlipidemic rats treated with standerd drug Atorvastatin. Hyperlipidemic rats treated with fruit extract did not show any lipid lowering effect. Cholesterol, triglycerides and LDL levels are significantly more than positive control group. Results of above experiment shows that Morinda citrifolia L fruit extract has strong antioxidant property whereas anticholesterol experiment did not contribute substantially to explicate the favorable outcome of fruit extract on positive control Since herbal medicines are needed to be used in higher doses and for relatively longer periods for permanent effects, hence further study is to be carried out on prolonged exposure of fruit extract to evaluate its beneficial effect against hyperlipidemia and hypercholesterolemia 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Shailesh Tawade, Dr. Rohini Sivabalan ANTIOXIDANT AND ANTICHOLESTEROL ACTIVITIES OF MORINDA CITRIFOLIA L. LINN IN RATS Indian Journal of Applied Research, Vol.4, Issue.7 July 2014

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