Volume : IV, Issue : XII, December - 2014

Antitumor Activity of Natural Compounds Against Ehrlich Ascites Carcinoma in Swiss Albino Mice

A. F. Abdel Aziz, Y. A Osman, Abir Jobara

Abstract :

<p><p>Natural products, from different biological origins, represent the main source of compounds used to synthesize drugs. For example, azurin, from Pseudomonas aeruginosa, and extracts from Viscum album, have< /> been reported to possess anticancer properties. They induce apoptosis, natural immunity in ill individuals, respectively.< /> The antitumor activity of azurin and water extract of Viscum album were evaluated against Ehrlich ascites carcinoma< /> (EAC) tumor inoculated in mammary glands of Swiss albino mice. The effect of treatment were performed either separately or in combination. Azurin was administered daily and the Viscum album was given three times a week, for 21< /> days. After administration of the last dose and 18h fasting ,animals were sacrificed and blood were collected for analysis. Several parameters were measured to evaluate the effect of azurin and Viscum album on the growth of tumor: life< /> span of EAC beå hosts and simultaneous alterations in the oxidative stress, superoxide dismutase (SOD) Catalase< /> (CAT) reduced glutathione (GSH) and Malondialdehyde (MDA) , tumor necrosis factor (TNF–α), Interleukin–10 (IL–10).< /> Each of the two compounds increased the life span of EAC tumor–beå mice, (SOD) , (GSH) and (CAT) levels. However, the MDA. IL–10 and TNF–α were decreased in the studied groups relative to the negative control group. A combination of azurin and Viscum album extract greatly improved all measured parameters after infected by EAC.</p></p>

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A.F.Abdel-Aziz Antitumor Activity of Natural Compounds Against Ehrlich Ascites Carcinoma in Swiss Albino Mice Indian Journal of Applied Research, Vol.4, Issue : 12 December 2014

Number of Downloads : 637

References :