Volume : VIII, Issue : VI, June - 2018

APOPTOTIC INDEX– A SIGNIFICANT BIOMARKER IN SPECTRUM OF CERVICAL LESIONS ON PAP SMEAR EXAMINATION

Dr Natasha Makkar

Abstract :

BACKGROUND– Cervical cancer is second most common malignancy. The Pap test, a significant screening tool, has certain subjective limitations. Specific biomarkers are needed to aid diagnosis.Apoptosis  is  easily  discernible  in  Pap  smears  in form of karyorrhexis, karyolysis  and  condensation  of  chromatin.This study was done to evaluate significance of apoptosis in cervical lesions.

METHODS– The study was conducted on Pap stained smears.Apoptotic index was calculated in each case. The lesions were divided into different categories and mean apoptotic index was calculated for each category. Statistical evaluation was carried out using Student t test.

RESULTS– Total 426 smears,the most common lesion

was inflammatory (43.7%) and least common was invasive carcinoma (4.2%). Invasive tumours had a significantly higher mean apoptotic index.

CONCLUSION– Apoptotic index  increases  with  increasing  grade  of  dysplasia. Apoptotic index is a useful biomarker to evaluate proliferative activity in cervical lesions.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

DR NATASHA MAKKAR, APOPTOTIC INDEX– A SIGNIFICANT BIOMARKER IN SPECTRUM OF CERVICAL LESIONS ON PAP SMEAR EXAMINATION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018

Number of Downloads : 179

References :