APPLICATION OF NEW HERBAL PESSARIES FOR THE TREATMENT OF THE LOWER GENITAL TRACT INFECTIONS

OreÃ…�‚¡Ã„�‚anin ViÃ…�‚¡nja; Findri GuÃ…�‚¡tek Ã…�‚ tefica; Hunjak BlaÃ…�‚¾enka

Volume : V, Issue : VI, June - 2015

APPLICATION OF NEW HERBAL PESSARIES FOR THE TREATMENT OF THE LOWER GENITAL TRACT INFECTIONS

Ore Sbquo Sbquo Anin Vi Sbquo Nja, Findri Gu Sbquo Tek Sbquo Tefica, Hunjak Bla Sbquo Enka

Abstract :

The main purpose of this work was to test the efficiency of newly developed herbal pessaries to prevent antibiotic–associated yeast infection during the treatment of Ureaplasma urealytium with doxycycline. Besides, the influence of the pessaries on the efficacy of the treatment of other bacterial, yeast and viral infections as well as low grade cervical intraepithelial lesions was also assessed. 93 women in the age range from ranged 19 to 64 years (34.4±9.3) represented experimental group and 97 women ranging from 22 to 60 years (32.7±6.3) represented control group, both infected with Ureaplasma urealytium were included in the study. The patients from the experimental group were treated with doxycycline for 12 days and locally for 10 days with new herbal pessaries while the control group was treated with doxycycline and gyno–daktarin pessaries. Significantly higher efficiency was obtained for the experimental group (x2 =8.39; P=0.0038) in eradication of U. urealytium (91.5%) compared to the control group (69.1%). Besides, complete eradication of M. hominis and C. trachomatis was also observed in the experimental group. All the swabs were negative to Candida sp. following the treatment with herbal pessaries compared to 26.8% positive swabs in the case of gyno–daktarin treatment. A significant improvement was also observed in the results of Pap test following the treatment with new herbal pessaries (x2 = 23.3; P < 0.0000). Among the predictor variables, the type of the therapy had the highest, statistically significant influence on the outcome of the therapy. The synergistic effect of the medicinal plants with well known wound healing, anti–inflammatory, antimicrobial and antiviral properties could be responsible for high treatment potential of the p