Volume : III, Issue : IX, September - 2013

Application of Polyvinylpyrolidone Nanofibers in Enhancement of Solubility of Glibenclamide Drug

Mr. Vishal Pawar

Abstract :

Nanofibers made from polyvinylpyrolidone (PVP) can be used for the enhancement of the solubility of the insoluble or poorly water soluble drugs like Glibenclamide. The solubility of the drug is very important in pharmacokinetics for taking effect. The polyvinylpyrolidone is an n–vinyl polymer which is hygroscopic in nature and absorbs water immediately and mix with the water. Glibenclamide is an important drug in the type II diabetes. Nanofibers are helpful in the solubility of drug. The nanofibers are used for this purpose because these are very fragile and porous in nature and can be easily soluble. The Electrospin machine is used for the production of the nanofibers in which the PVP and the well mixed solution of the drug is used for the production of the Glibenclamide incorporated PVP nanofibers. Nanofibers are characterized using scanning electron microscope. The rate of dissolution is carried out using the dissolution apparatus. The nanofibers are helpful for increasing bioavailability of Glibenclamide drug.  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Mr. Vishal Pawar Application of Polyvinylpyrolidone Nanofibers in Enhancement of Solubility of Glibenclamide Drug Indian Journal of Applied Research, Vol.III, Issue.IX September 2013

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