ASPARTAME�INDUCED OXIDATIVE STRESS ON LIVER AND KIDNEY IN NORMAL AND DIABETIC ADULT MALE RATS

Gamal H. El�Sokkary; Bothaina M. Khidr; Shaimaa M.M. Saleh

Volume : VI, Issue : VIII, August - 2016

ASPARTAME�INDUCED OXIDATIVE STRESS ON LIVER AND KIDNEY IN NORMAL AND DIABETIC ADULT MALE RATS

Gamal H. El Sokkary, Bothaina M. Khidr, Shaimaa M. M. Saleh

Abstract :

The present study was designed to evaluate whether the daily administration of aspartame (ASP) by 200 mg/kg bwt for 4 weeks induces oxidative stress and biochemical changes in the liver and kidney of rats. Forty adult male albino rats were divided into four equal groups {control, ASP (200 mg/kg bwt), streptozotocin–induced diabetes (D) (70 mg/kg bwt), and D+ASP). Levels of lipid peroxidation (LPO) products a long with liver and kidney functions were investigated. The results revealed increase of LPO in ASP group compared to control and decrease in D+ASP groups compared to ASP. AST and ALT activities were increased in ASP and D groups compared to control. Creatinine level and urea concentration showed an elevation in all treated groups compared to control. This study improved that ASP administration may be responsible for oxidative stress that induce disturbance of liver and kidney function.