ASSESMENT OF PREGNANCY ASSOCIATED PLASMA PROTEIN – A (PAPP– A) AS A PREDICTOR OF ACUTE CORONORY SYNDROME IN PATIENTS PRESENTING WITH CHEST PAIN

Dr. K. Sreekanth; Dr. K.V.L. Sudha Rani; Dr. K. Udaya Bindu

Volume : VIII, Issue : VIII, August - 2018

ASSESMENT OF PREGNANCY ASSOCIATED PLASMA PROTEIN – A (PAPP– A) AS A PREDICTOR OF ACUTE CORONORY SYNDROME IN PATIENTS PRESENTING WITH CHEST PAIN

Dr. K. Sreekanth, Dr. K. V. L. Sudha Rani, Dr. K. Udaya Bindu

Abstract :

Acute coronary syndromes (ACS) are a major cause of morbidity and mortality in the world today. Early diagnosis limits myocardial damage in ACS patients. Presently, we use cardiac troponins I and T which are sensitive and specific biomarkers for diagnosing ACS, but they are released in circulation only after tissue damage. There is a need of new biomarkers that would appear in the circulation before significant myocardial necrosis develops.Lately pregnancy associated plasma protein– A (PAPP– A)has emerged as an interesting bio marker in this context.The present study is undertaken in patients admitted to the emergency department with chest pain and finally diagnosed as ACSat Osmania Govt. hospital.In this study, total 88 subjects were included, out of them 50 were patients of acute coronary syndrome and 38 were healthy controls.The mean PAPP–A levels were estimated in both ACS patients and healthy controls. Mean PAPP–A levels were significantly elevated 0.673+ 1.2 in ACS patients compared to 0.1025+ 0.38 in healthy control (P < 0.001). The mean Troponin–I levels were estimated in both ACS patients and healthy controls 17.61+ 19 in ACS patients and 0.702+ 0.8 in healthy controls, P< 0.001