ASSESSMENT OF COGNITIVE FUNCTIONS OF NON DIABETIC CHRONIC KIDNEY DISEASE PATIENTS (STAGE 5D) AND ITS CORRELATION WITH SERUM URIC ACID LEVELS

Dr. K.Archanaa; Dr. D.Selvam

Volume : IX, Issue : VIII, August - 2019

ASSESSMENT OF COGNITIVE FUNCTIONS OF NON DIABETIC CHRONIC KIDNEY DISEASE PATIENTS (STAGE 5D) AND ITS CORRELATION WITH SERUM URIC ACID LEVELS

Dr. K. Archanaa, Dr. D. Selvam

Abstract :

Background: In recent years, Chronic Kidney Disease (CKD) is becoming more prevalent in developing countries like India because of poor control of diabetes and hypertension. Cognitive deterioration progresses as disease increase in its severity. Many studies proved diabetes as an importatnt risk factor for cognitive deterioration. This study focuses mainly over the role of uremic toxins, mainly uric acid in cognitive deterioration in non diabetic CKD patients. Methods: After getting informed consent, cognitive function of 30 non diabetic CKD and age and sex matched controls was assessed by NIMHANS Neuropsychology battery 2004 and comparison between these 2 groups by student t tests. Later using Pearson’s correlation, relationship between each and every cognitive domain & serum uric acid level were analysed. Results: Cognitive function scores of non diabetic CKD patients was less than their age and sex matched controls. These results were statistically significant with P value less than 0.001. As serum uric acid level goes high, cognitive function test scores reduces as well as they take more time to perform the test and commit more errors. So Time based scores & error based scores were more & Hit based scores were less in non diabetic CKD patients compared to their controls. Conclusion: In this study it is found out that uremic toxins causes cognitive deterioration in non diabetic CKD patients. Early identification and correcting these factors may improve the cognitive function, which in turn enhances quality of living and life expectancy of CKD patient